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Abstract
Neonatal seizures lead to release of certain neurohormones in
relation to the region from which it originates to which it spreads. These
hormones are growth hormone, cortisol and prolactin (Kilic et al., 1999).
Prolactin is the most specific neurohormone that is elevated after seizures
(Morales et al., 1995). Post-ictal prolactin level can be used as a marker in differentiation of seizures as well as providing important information about their etiology (Kilic et al., 1999).
Our study aimed at determination of the clinical value of serum
prolactin level as a diagnostic aid in neonatal seizures and its relation to
etiology, type and duration of seizures. This study was conducted on 55 neonates, they were divided into two
groups: Patients group: Comprised 35 full term neonates with neonatal seizures admitted to NICU of Zagazig University HospitaL Their mean gestational
age was 38.6±1.2 weeks, their mean birth weight was3.6±0.56 Kg. They
were 22 (63%) males and 13 (37%) females, 23 (66%) of them were
delivered by vaginal delivery, and 12 (34%) by C.s
Any patient on dopamine agonist or antagonist medication that
affects prolactin levels were excluded. Also, all preterm neonates were
excluded. Control group: Comprised 20 healthy full term neonates, obtained from post natal ward of Obstetric and Gynecology Hospital of Zagazig
University. Their mean=gestational age was 38A±L2 weeks, their mean.