الفهرس 
AbstractOnly 14 pages are availabe for public view
 |  | from | 213 |  |  |
| | | from | 213 | | |
Abstract
Cyanuration of 4-chlorobenzaldehyde (1), cyclohexanone (2a) and 2-methylcyclohexanone (2b) yielded the racemic 2-(4-chlorophenyl)-2-hydroxyethanenitrile (R,S)-3, 1-hydroxycyclohexanecarbonitrile 21a and (R,S)-1-hydroxy-2-methylcyclohexanecarbonitrile (R,S)-21b,respectively. The same reaction can be completed by using acetone cyanohydrin (4) as a transcyanating agent. The optically active cyanohydrins (R)-3 and (R)-21b could be respectively obtained by hydrocyanation of 1 and 2b using (R)-hydroxynitrile lyase (R)-PaHNL [EC 4.1.2.10] from almonds (Prunus amygdalus) as a chiral catalyst.