الفهرس 
Cover PageOnly 14 pages are availabe for public view
 |  | from | 197 |  |  |
| | | from | 197 | | |
Abstract
This study was conducted to give an overview on the effect of some medicinal plants as Arctuim lappa and Curcuma longa as hepatoprotective agents in experimentally intoxicated rats using CCl4 as toxic model substance throughout the assessment of different hematological, biochemical and immunological parameters as well as histopathological alterations at different intervals. The study revealed non significant changes in erythrogram examination in all experimental groups compared to control negative allover the experimental period. On the contrary, marked elevation of TLC was observed at the fourth week in rats administrated A.l, C.l. individually or in combination. Serum biochemical analysis revealed drastic elevation in the activities of serum transaminases and ALP in control positive group. Also, BUN, creatinine, calcium and phosphorus showed significant elevation in CCl4 intoxicated group compared to control negative. Meantime, serum total protein, lipid profile and serum glucose level showed significant decrease in CCl4 intoxicated rats along the experimental period. Dietary Arctuim lappa and Curcuma longa administration to CCl4 intoxicated rats’ revealed significant improvement and relieved the toxic effect encountered by CCl4 compared to control negative group allover the experimental period. Evaluation of cell mediated immune response revealed significant improvement in phagocytic activity in group administrated A.l. and C.l. compared to control negative group. In summary, it could be clear that combination of plants, Arctuim lappa and Curcuma longa treated groups respectively possess considerable improvement in liver and kidney architecture and effectively inhibit the liver injury induced by CCl4 and enhance immune response and may be developed into clinical application.