الفهرس 
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Abstract
Coadministration of glibenclamide with gentamicin to alloxan diabetic rats caused a significant decrease in glucose level and significant increases in concentrations of cholesterol, urea, creatinine and uric acid in the serum. Concomitant administration of glibenclamide and diclofenac produced significant increases in the activity of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase as well as creatinine concentration in the serum. Concurrent administration of glibenclamide with both gentamicin and diclofenac to diabetic rats induced a significant decrease in serum glucose level and significant increases in liver enzymes, cholesterol, urea, creatinine and uric acid concentrations in the serum. It also caused marked histopathological lesions in both liver and kidneys. Therefore, eo administration of the three drugs together is contraindicated to avoid the hepatonephrotoxic effect and the marked reduction of blood glucose level that may cause hypoglycemic coma.