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العنوان
Pharmacokinetic and tissue residues of enrofloxacin in healthy and Pasteurella multocida infected rabbits /
المؤلف
Shaheen, Hassan Ahmed Mohamed.
هيئة الاعداد
باحث / حسن أحمد محمد شاهين
مشرف / / مصطفى عباس شلبي
مشرف / جمال عبد الحكيم سليمان
مشرف / جيهان محمد كامل
الموضوع
rabbits. Pharmacokinetics. Pasteurella multocida.
تاريخ النشر
2010.
عدد الصفحات
72 Leaves :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
البيطري
الناشر
تاريخ الإجازة
1/1/2010
مكان الإجازة
جامعة القاهرة - كلية الطب البيطري - Pharmacology
الفهرس
Only 14 pages are availabe for public view

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from 87

Abstract

The results showed that after oral administration of enrofloxacin in normal healthy rabbits, its pharmacokinetic profile characterized by rapid oral absorption, large volume of distribution, prolonged elimination half live and low tissue residues. The results also revealed that the experimental infection of rabbits by Pasteurella multocida microorganisms induced positive changes in the pharmacokinetic properties of enrofloxacin. Therefore, this study recommends that the changes in pharmacokinetic profile of enrofloxacin should be taken in consideration during its clinical use for the treatment of pasteurellosis in rabbits.