الفهرس 
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Abstract
The objective of the present study was directed to perform a comparative study for the protective efficacy of different vaccine
tormulauons either single toxoid vaccine or combined with Clostridial toxins to evoke protection against Cascous lymphadenitis
and Clostridial diseases in sheep. Four different vaccincs were formulated and investigated tor their ctficicncy in protecting
sheep against C pseudotuberculosrs. It was observed that antibody titcrs 01” sheep vaccinated \I ith tuxuid 1’1.1) vaccine showed
the 11Igllestliter 01” I’I.D antibodv So. combination ottuxnrd Pll) allll (·Il)stmlial l·aCC1l1C tllgctlln stilllulatcd humoral immune
response. It was observed that sheep vaccinated with toxoid 1’1.1) vaccine elicited pllsitlle prolucrauon response and strong
cellular immune response. The present studv concluded that the toxoid PLD alone stimulated both humoral and cell mediated
unmunc response and provided high level 01” protection against cascous lymphadenitis In sheep (9 I u/,,) and also the combined
vaccine composed 01” toxoid I’LD and clostridial vaccine succeeded in stimulating both humoral and cell mediated immune
response. hut protection was less than vaccination with toxoid I’Ll) vaccine alone.