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Abstract
Greater demand in body aesthetic medicine for non invasive procedures has motivated researchers to develop new techniques to replace traditional treatments for body contouring while avoiding invasive techniques and their associated disadvantages. (41-43)
The practice of injecting phosphatidylcholine/ sodium deoxycholate compounds into subcutaneous fat is growing rapidly. As with any new procedure, a standard of practice should be developed so that practitioners maintain patient safety as the primary goal. Efficacy and predictability of outcome are another priority. As injection lipolysis becomes more accepted, many standards are being set, such as indications, contraindications, acceptable postinjection sequelae, best regions to treat, regions to avoid, and expected outcomes.
Injection lipolysis could be used to treat many areas in the body. The abdomen, the back region, the flanks, the submental neck and submandibular jaw line are very responsive sites. Also the upper arms, thighs, and knees are responsive sites when the correct technique is used. The quality and quantity of fat determines the degree of responsiveness.
The aim of this work was directed to compare the efficacy of injection lipolysis using PC/DC and using DC only in treatment of localized fat accumulations.
This study was carried out on twenty female patients with age range from 20 to 55 years old complaining of localized lower abdominal fat and who satisfied the entry criteria. Patients were divided randomly into two groups, the PC/DC group and the DC group, each of which consisted of ten cases.
Drugs were injected manually using a 5cc syringe with 30G, 13mm needle tip applied to it. Injection was done with the bevel directed upwards to the depth of (10-13mm). An amount of 0.4ml was injected in each prick at a two cm distance.
To have comparable values between the two injected materials, the PC/DC cases were given 2 vials (10ml) and the DC cases were given 8ml.
There was moderate improvement in circumferential measurement in both groups that ran parallel. The side effect profile of both materials was localized and resolvable. This included pain, erythema, bruises and sensitivity to touch. Also burning sensation, swelling, induration and itching. Although pain, burning sensation and induration occurred more and lasted for a longer period in the DC group. Subcutaneous nodules were clinically more evident and lasted longer (for two months) in the DC group. Diarrhea or steatorrhea occurred in some cases of both groups too.
Of greatest interest was the conclusion confirming that DC is an active substance in inducing fat cell lysis in injection lipolysis. Although it has some more side effects than the PC/DC formula. That is why the PC/DC formula is more recommended to obtain faster results with less side effect occurrence and duration. To ensure best results, sessions should be repeated with final judgment of treatment outcome.