الفهرس 
Hepatitis C viral infectionOnly 14 pages are availabe for public view
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Abstract
Thrombocytopenia is a relatively common extra hepatic manifestation of hepatitis C; thrombocytopenia can impact routine care of patients with, potentially postponing or interfering with diagnostic and therapeutic procedures including liver biopsy, antiviral therapy and medically indicated or elective surgery. The aims of present study were to evaluate the prevalence of thrombocytopenia in chronic hepatitis C patients in the presence or absence of cirrhosis and assess the relationship between HCV infection and frequency of thrombocytopenia.
Data of 625 patients with chronic hepatitis C from Cairo Liver Center from 2005 to 2008 .These data include full history, clinical assessment, laboratory investigations which includes: (complete blood count (CBC), liver biochemical profile, kidney function tests and PCR if present), abdominal ultrasound and upper endoscopy if found.
The prevalence of thrombocytopenia among our studied patients was 288 out of 625 (46.08%). mild thrombocytopenia was the most common grade as we find its prevalence (71.18%) followed by moderate thrombocytopenia (20.49%) and lastly severe thrombocytopenia (8.33%). The prevalence of thrombocytopenia in cirrhotic and non cirrhotic patients (75.2%) and (21.3%) respectively.
In present study cirrhotic patients were classified according to Child-Pugh classification into class A, B and C.
The prevalence of thrombocytopenia increases significantly with the progress of Child-Pough class (P=0.000).
Thrombocytopenia significantly occurs more in older ages, high AST level, high total bilirubin, low albumin, low Prothrombin, low total leukocyte count and low hemoglobin level. Also there was high correlation between thrombocytopenia and portal hypertension, as thrombocytopenia is statistically significant with splenomegaly, dilated portal vein and the presence of oesophageal varices.