الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 74 |  |  |
| | | from | 74 | | |
Abstract
The aim of the present study was to evaluate the role of Ki-67 and p53 biomarkers in endometrial hyperplasia compared to endometrial intraepithelial neoplasia and endometrial carcinoma in patients with perimenopausal and postmenopausal uterine bleeding.
This study was carried out on 50 patients divided into three groups according to histopathological examination.
GI: Fifteen cases (30%) included 8 cases of complex endometrial hyperplasia without atypia and 7 cases of simple endometrial hyperplasia without atypia.
GII: Twenty-five cases (50%) included 7 cases of complex endometrial hyperplasia with atypia, 13 cases of simple endometrial hyperplasia with atypia and 5 cases of endometrial intraepithelial neoplasia.
GIII: Ten cases (20%) of different types and grades of endometrial carcinoma.
Our study demonstrated that:
• P53 biomarker showed low-expression (staining index 4) in all cases of simple and complex EH without atypia. However, it was highly-expressed (staining index > 4) in all cases of simple and complex EH with atypia, cases of EIN and that of endometrial carcinoma.
• Ki-67 biomarker showed low-expression (staining index 4) in 10 cases of simple and complex EH without atypia. However, it was highly-expressed (staining index > 4) in 5 cases of simple and complex EH without atypia, all cases of simple and complex EH with atypia, cases of EIN and that of endometrial carcinoma.
• Regarding staining index of ki-67 and P53 biomarkers, there was a significant statistical difference between group I and group II and between group I and group III, but there was no significant statistical difference between group II and group III as regards staining index.
• There was no significant statistical difference between the three studied groups as regards gravidity, parity, BMI, age, HRT, smoking, OCs, DM and HTN.
• There was a significant statistical difference between group I and III as regards tamoxifen use and there was a significant statistical difference between group I, III and between group II, III as regards endometrial thickness by TVUS.
• The sensitivity of both P53 and Ki-67 biomarkers was 97.14%, while the specificity of P53 was 100% and that of Ki-67 was 66.67%. This means that P53 was more specific than Ki-67 in detection of cases of endometrial hyperplasia, EIN and endometrial carcinoma.
CO