الفهرس 
abstractOnly 14 pages are availabe for public view
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Abstract
Superficial Fungal infection is the most common fungal infection in all
countries especially tropical areas like Egypt. Although azoles antifungal are the
most commonly used antifungal in clinical treatment of both superficial and
systemic fungal infections, triazoles topical antifungal agents are not
commercially available in spite of its efficiency and safety over imidazoles and
polyenes, which are available commercially and heavily used. Many azoles are
poorly water soluble, which limits their bioavailability and antifungal effects.
The objective of the present study was to design and develop topical
pharmaceutically acceptable nonionic surfactant systems for poorly watersoluble
compounds, triazole antifungal agents such as fluconazole and
terconazole. The development of topical microemulsion systems is an objective
of the present study. Several of the systems have been developed and evaluated
for their physico-chemical characteristics, invitro liberation behavior, skin
irritation, microbiological efficacy of medicated and nonmedicated formulae
have been studied alone and then compared with some commercial
preparations, and clinical activity was also evaluated. Therefore, the work in
this thesis is divided into two chapters:
- UChapter I: Formulation and Evaluation of Topical Medicated