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Abstract The oral cavity is highly acceptable by patients. The mucosa is relatively permeable with a rich blood supply. Furthermore, oral transmucosal drug delivery bypasses first pass effect and avoids presystemic elimination in the GI tract. These factors make the oral mucosal cavity a very attractive and feasible site for systemic drug delivery. The work in this thesis was divided into two parts, each part containing two chapters: Part One: Chapter (1): Formulation and evaluation of verapamil Hcl buccoadhesive tablets. Chapter (2): In-vivo evaluation of selected verapamil Hcl buccoadhesive tablets. Part Two: Chapter (1): Formulation and evaluation of diclofenac sodium buccoadhesive tablets. Chapter (2): In-vivo evaluation of selected diclofenac sodium buccoadhesive tablets |