الفهرس 
URIC ACIDOnly 14 pages are availabe for public view
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Abstract
SUMMARY
Uric acid is the final breakdown product of purine degra-dation in humans. Hyperuricemia results from increased production, decreased exertion or a combination of both.
During adulthood, plasma concentration rises over time and varies with height, body weight, blood pressure, renal function, and diet.
This study shows prevalence of hyperuricemia in a sample of Egyptian hypertensive patients and and to evaluate uric acid metabolism and excretion among hypertensive subjects with normal renal functions.
We conducted this study on 303 hypertensive patients selected from the outpatient clinic of Electricity hospital and Ain Shams University hospital.
Patients were divided into 2 groups according to the level of uric acid: Group 1 composed of hypertensive hyperuricemic patients and Group 2 composed of hypertensive normouricemic patients.
All studied patients were subjected to complete medical history and detailed clinical examination including body mass index (BMI), routine laboratory test including complete blood count (CBC), s.creatinine, s.blood urea nitrogen, s.fasting blood sugar, s.cholesterol, s.triglycerides, s.uric acid, s.sodium, s.potassium, urinary uric acid, urinary creatinine, urinary uric acid to creatinine ratio and fractional excretion of uric acid.
In our study we found the prevalence of hyperuricemia in the studied hypertensive patients was 55.4%.
In the current study, uric acid correlated significantly with age, BMI. When comparing group1 with group 2 BMI is statistically significantly higher with group 1. Also, regarding serum triglycerides and serum cholesterol, it was significantly higher with group 1(p=0.011).
Serum uric acid was significantly correlated with systolic blood pressure but not with diastolic blood pressure. No significant difference between group 1 and group 2 as regard SBP, DBP or blood pressure control.
We found that hyperuricemia was present in 46.4% of controlled blood pressure and in 53.6% of uncontrolled blood pressure.
There were no significant correlation between uric acid and cardiovascular complications in our study and was no significant difference in cardiovascular disease when comparing group1 with group 2.
Uric acid is statistically correlated with urea and creatinine. Serum uric acid was significantly correlated to urinary uric acid, urinary creatinine and negatively correlated to fractional excretion of uric acid (FEUA). Also, when comparing group1 with group 2 significant differences was found higher with urinary uric acid (Uua), urinary creatinine (Ucr) and urinary uric acid to creatinine ratio with group 1 and significantly lower with fractional excretion of uric acid (FEUA).