الفهرس 
Female breastOnly 14 pages are availabe for public view
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Abstract
By the end of the last century, surgical management of breast cancer has changed dramatically. It has evolved from radical to conservative measures. It started with extended radical or radical mastectomy followed by modified radical mastectomy ending up with conservative breast surgery in the form of wide local excsion or quadrantectomy with complete axillary lymph node dissection.
Adopting the same approach in dealing with the axillary lymph nodes in case of breast cancer, surgical management of the axilla in breast cancer has evolved from complete axillary lymph node dissection to more conservative measure, to partial ALND and axillary sampling. Lately the SLNB approach was adopted in staging of the axilla.
This study was implied on 20 female patients with early breast cancer (T1-T2, NO, MO) with clinically negative axilla (proved by ultrasound evaluation), to evaluate the value of sentinel lymph node biopsy in management of early breast cancer in order to avoid the complications that may occur as a result of unnecessary complete axillary dissection.
Sentinel lymph node was identified by injecting 5 ml of Patent Blue-V Dye either subareolar or peritumoral or combined both techniques. The operative procedures was started either in the form of modified radical mastectomy, wide local excision or quadrantectomy. Then meticulously dissecting the first encountered axillary lymph node that received the bluish color of the dye. Lastly, proceeding to complete axillary lymph node dissection to compare histopathological results of sentinel lymph node and the rest of axillary lymph nodes.
from this study we found that in patients with early breast cancer with clinically negative axillary lymph node involvement that SLNB can help as a good predictor for the status of axillary lymph nodes thus decreasing the complications associated with the standard axillary dissection. Also, the SLNB technique is much less invasive than the standard axillary dissection, sparing a lot of patients the morbidity of the procedure. Most important finding is that SLNB technique does not compromising the staging of the axilla.
In conclusion, SLNB technique proved its feasibility, safety and accuracy in the detection of lymphatic metasis in breast cancer patients. Histological examination of the SLNB reflects the status of the rest of the axillary lymph nodes.
SLNB without completion of ALND can safely replace ALND as the procedure of choice for axillary staging in breast cancer patients with a clinically negative axilla. It is a valuable technique, sparing patients from greater morbidity as well as having economic benefits for health care systems and patients. But good training of the surgical team is very important so as to minimize the false negative rates as much as possible.