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Abstract Plantar warts are extremely common and very painful. They are caused by human papilloma virus subtypes 1,2,4 and 63,with types 2 and 4 composing most of the mosaic type plantar warts and type 1 human papilloma virus has been shown to have the highest viral particle density. Our aim from this study was to assess and compare the efficacy of intralesional bleomycin and cryotherapy in treating plantar warts in the same group of patients. Our study included thirty patients with total 142 warts, the warts in each patient were equally divided into two groups, group A lesions received 0.5 unit/ml intralesional bleomycin and group B lesions received cryotherapy (double-freeze thaw cycle) every 2 weeks for a maximum of four sessions. Complete clearance was achieved in (93.3%) of patients treated with bleomycin and in (70%) of patients treated with cryotherapy. The recurrence rate was (10.7%) for bleomycin treated patients and (71.4%) for cryotherapy treated patients. The mean number of sessions needed to achieve complete clearance was two sessions for bleomycin and three sessions for cryotherapy. In conclusion when comparing bleomycin with cryotherapy, the former showed higher percentage of clearance rate, less number of sessions needed for complete clearance, lower recurrence rate and less side effects, making bleomycin an excellent treatment option for plantar warts. |