الفهرس 
introductionOnly 14 pages are availabe for public view
 |  | from | 124 |  |  |
| | | from | 124 | | |
Abstract
Periodontitis is an inflammatory disease of supporting tissue of teeth, caused y specbific microorganisms, resulting in progressive destruction of periodontal ligament and alveolar bone with pocket formation. Several cytokines have been reported to act as chemoattractants for migrating epithelial cells, and facilitating vascular epithelial growth during pocket formation, one of this is hepatocyte growth factor ( HGF).
Aim of the study: This study is designed to evaluate hepatocyte growth factor (HGF) level in gingival crevicular fluid (GCF) in periodontitis patients before and after surgical and non-surgical treatment.
Materials and Methods: Forty subjects (9 males and 31 females) ranging in age from 30 to 60 years were included in this study. All the subjects were divided into 4 groups based on gingival index (GI), probing depth (PD), clinical attachment loss (CAL) as the following: group 1 (healthy subjects): Included 10 patients with clinically healthy periodontium, with no evidence of disease.
group II (gingivitis patients): Included 10 patients whose gingiva show clinical signs of inflammation and no evidence of attachment loss.
group III (chronic periodontitis patients of non surgical periodontal treatment): Included 10 patients who show clinical signs of gingival inflammation and attachment loss. This group was treated by scaling and root planing.
group IV (chronic periodontitis patients of surgical periodontal treatment): Included 10 patients, it has the same criteria of group III but treated by modified Widman flap surgery.
The probing of inflamed sites and all clinical measurements were performed the day before GCF collection. Periodontal treatment was performed for chronic periodontitis patients after GCF collection. After 8 weeks, GCF is collected from the same sites in subjects of group III and IV. The level of HGF was estimated using enzyme-linked immunosorbent assay.
Results: the highest mean HGF concentrations were observed for groups III and IV, and the lowest mean concentration was observed for group I. following periodontal treatment either surgical or non-surgical, the mean HGF concentrations were decreased which was statistically significant.
Conclusion: HGF level increased proportionally in GCF with progression of periodontal disease suggesting that HGF plays a key role in periodontal disease progression. Following either surgical or non-surgical treatment, HGF levels decreased significantly suggesting that HGF could be useful for monitoring the response to periodontal therapy.