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Abstract Cancer is considered one of the most common causes of mortality worldwide. The target of much research has been on the discovery of natural and synthetic compounds that can be used in the prevention and / or treatment of cancer. Natural products of either plant or animal origin that exhibited anti- tumor activities have been discovered. Two hundred and fifty adult female Swiss albino mice were divided into fives groups. Gp.(l) was the negative control, gp.(2) was Lp inoculated with 2.5 xl 06 EAC, gp.(3)was Lp inoculated with 2.5 x l 06 EAC and orally treated with propolis(50 mg / kg b wt.),gp(4) was l.p inoculated with 2.5 xl06 EAC and orally treated with methotrexate (O.4mg / kg b wt.) and gp.(5) was Lp inoculated with 2.5 xl 06 EAC and orally treated with combination of propolis and methotrexate. Survival analysis was calculated, and then mice were sacrificed. Blood samples for hematological and immunological studies, serum samples for biochemical studies, tissue specimens were collected from the liver, lung, kidneys, spleen and peritoneum for histopathological examination. Liver tissue homogenate for antioxidant estimation. |