الفهرس | Only 14 pages are availabe for public view |
Abstract Infections are a frequent and important cases of morbidity and mortality in neonatal period. The term at risk means neonates who should be under close observation by physicians and nurses. This study included (50) neonates: 25 patients with clinical significant and symptoms highly suggestive of neonatal septicemia which was confirmed in all the (25) patient by positive blood cultures. The septic group compared with another 25 healthy normal neonates as a control group. All cases and controls were subjected to the following: I ) Full general examination including all systems. 2) Bacteriological study, including blood culture. 3) Hematological study: C.B.C , E.S.R , c.R.P and HSS which is a score of for each of seven findings: abnormal total leukocytic count, abnormal total neutrophil (PMN) count , elevated immature PMN count , elevated immature to total PMN ratio, immature to mature PMN ratio 2: 0.3 , platelet count ~ 150.000 and pronuced degenerative changes in PMNs. The test is .ve above or equal to 3 (2:3). The most prominent clinical significant of septicemic group were poor sucking (96%) , sluggish Moro reflex (92%) , lethargy (80%)) temp instability (68%), oral thrush (48%) respiratory distress (44%) . In present study all 25 septic neonates had positive blood culture. The frequency of organism isolated by blood culture were staph (24%) . E.coli (24%) G.B.S (\6%) ,Enterobacter (12%), citrobacter (8%) and each ofstrep pneumonia, proteus, psedomonas , and H.influenza 4% . _ Elevated E.SR and CR.P were also found to be helpful test in diagnosis of neonatal septicemia. _ In our study we found that from (25) septic neonates (23) had positive (HSS) and only (2) cases had negative score so the sensitivity ofHSS is (92%) and specitity (100%) and + ve & - ve predictive value was (92%), (100%) respectively the higher the score the greater the likehood of sepsis. This can be proved by our result, sever cases (+++ ve CR.P) had the highest score. There is no direct relation between Eosinophilia and septicemia. The mortality rate of all the septicemia group was (60%) (15 septic neonates was died ) . The most important factors affect mortality rate in our study was CR.P , E.S.R , HSS . For the previous points mentioned the HSS can be used for diagnosis, prognosis . measure the severity of septicemia. |