الفهرس 
Anatomy of the corneaOnly 14 pages are availabe for public view
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Abstract
Penetrating keratoplasty is the most widely practiced type of transplantation in humans. Irreversible immune rejection of
the transplanted cornea is the major cause of human allograft
failure in the intermediate and late postoperative period. This
immunological process causes reversible or irreversible damage
to the grafted cornea in several cases despite the use of intensive
immunosuppressive therapy. Corneal graft rejection comprises a
sequence of complex immune responses that involves the
recognition of the foreign histocompatibility antigens of the
corneal graft by the host’s immune system, leading to the
initiation of the immune response cascade.
Risk factors for corneal graft rejection include corneal
vascularization, anterior synechiae, irritating sutures, active
inflammation, regrafting, additional surgery, trauma, history of
graft rejection, recurrence of herpes, eccentric grafting and
corneal scarring on the graft.
Prevention of immune-mediated graft rejection aims at
minimizing antigenic difference between the host and the donor
tissue and reducing the antigenic load of donor tissue,
meticulous surgical technique, including avoiding decentration
of the recipient bed cut, optimal suturing, and good graft--host
apposition. Controlling the host immune response to the foreign