الفهرس 
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Abstract
End stage liver disease (ESLD) is a health problem worldwide. Liver transplantation is currently the only effective therapy.In Egypt, living donor liver transplantation has provided the only option for patient with ESLD.
In Egypt, the most common indication for liver transplantation is ESLD due to hepatitis C infection followed by selected hepatic malignancy (HCC)
Liver transplantation can be associated with numerous complications. Rejection and recurrent hepatitis C are considered the most common complications that affect liver transplantation.
Many prognostic factors affect the outcome of liver transplantation such as age of the donor, steatosis and presence of T cell subpobulation in both donor and recipient.
The present study is a retrospective study, including 38 needle liver biopsies, 19 biopsies before transplantation (from donors) and 19 after transplantation (from recipients) of which, 9 cases showed rejection and 10 cases showed recurrent hepatitis C.
The donor’s biopsies were examined by hematoxylin and eosin for portal inflammation, steatosis and spotty necrosis.
The relationship between the histological criteria of the donors (steatosis, spotty necrosis and inflammatory activity) and the post transplant complications (ACR and recurrent hepatitis C) were studied.
The recipient biopsies were examined by H&E to confirm diagnosis and then RAI score according to Banff schema (1997) and grade of recurrent hepatitis according to modified Knodell and Ishak(1995) were compared.
Anti CD4 and anti CD8 immunohistochemical staining were applied to detect and count CD4+ &CD8+ lymphocytes in portal tracts and hepatic lobules in relation to all lymphocyte in both donors and recipients.
The ratio of CD4 & CD8 + cells /all lymphocytes were calculate and
then the ratio of CD4 to CD8 was calculated and correlated to
clinicopathological findings.