الفهرس 
Materials and methodsOnly 14 pages are availabe for public view
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Abstract
The aminoglycoside antibiotics (gentamicin, tobramycin,
amikacin and netilmicin) are widely prescribed in clinical
medicine to treat serious infections (Bennett et al., 1982).
Nephrotoxicity is a major adverse effect of aminoglycoside
antibiotic agents.
This is a comparative study of nephrotoxicity of these
drugs in the hope that we can choose or recommend the best.
This study was conducted upon 35 patients divided into 4
groups according to the aminoglycoside used.
Blood urea and serum creatinine were measured before
treatment and on the third, sixth and tenth day of the treatment.
Creatinine clearance was measured before treatment and
on the tenth day of the treatment.
In this study, we found no wide variations in nephrotoxicity
between these aminoglycosides. The nephrotoxicity
of aminoglycosides is preventable and reversible.So, we advise
1J Adjusting the dose to be the minimal of therapeutic effect.
2J Adjusting the duration of treatment not to exceed ten days.
3J Patients should be well hydrated during therapy.
4J Monitoring the nephrotoxicity of the patient by measuring
serum creatinine on third day and toxicity must be considered
if it exceeds 31%.