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Abstract cotacts:This study was undertaken to study the effect of adding different types and levels of herbs extracts to obese rats diet on weight reduction and modify lipid profile Adult male albino rats , Sprague Dawley strain 100-120 g were divided into 12 groups , 6 rats each . All rats were fed on hyperlipidemic diet for 3 weeks except one was fed on standard diet (negative control) . All groups of rats fed the experimental diet (standard) for 4 weeks as the following : casein (negative control) ; casin after hyperlipidemic diet (positive control) ; casein in addition to 0.5% juniper extract ; casein in addition to 0.5rhubarb extract ; casein in addition to 0.5marjoram extract ; casein in addition to 1juniper extract ; casein in addition to 1rhubarb extract ; casein in addition to 1marjoram extract ; casein in addition to 0.5% ( juniper + rhubarb )extracts ; casein in addition to 0.5(juniper + marjoram )extracts ; casein in addition to 0.5% ( marjoram + rhubarb) extracts ; casein in addition to 0.5% ( juniper + rhubarb + marjoram) extracts . At the end of the experimental period all groups of rats were sacrificed and blood samples were subjected to determine total lipid ; phospholipid ; T.C ; T.G ; HDL-C ; LDL-C and VLDL-C . The results revealed that groups of rats received rhubarb extract at (0.5% and 1% levels) showed a significant reduction in food intake ; body weight gain and F.E.R (P 0.01) than other groups .Groups of rats received marjoram extract at (0.5% and 1levels) showed a significant decreased in serum total lipid; T.C ; T.G ; LDL-C and VLDL-C and increased in serum HDL-C than other groups . Group of rats received (rhubarb + marjoram) extracts showed a significant reduction in body weight gain ; F.E.R ; total lipid ; T.C ; T.G ; LDL-C and VLDL-C and increased in serum HDL-C 0.01) than other groups . |