الفهرس 
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Abstract
Keloid is a common presenting complaint in the primary care clinic. This condition represents a formidable challenge, as recurrence is often difficult to prevent despite the use of multiple therapeutic interventions. Part of the reason for the absence of a definitive treatment is the incomplete understanding of the pathogenesis of keloid formation, which creates a frustrating situation for both physician and patient.
In vitro studies of fibroblast autocrine characteristics have been confounded by the presence of serum containing tissue culture media because serum contains growth factors. The serum¬free model can be used to quantitatively measure autocrine secretions production by cells. Since the only growth factors present in this model are products of the fibroblasts themselves, autocrine products may be assayed without exogenous contributions.