الفهرس 
1. IntroductionOnly 14 pages are availabe for public view
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Abstract
Nitroxyl (HNO) is a nitrogen-containing compound chemically related to the well-known signaling agent nitric oxide (NO) and demonstrates distinct chemistry and biology compared to NO. Administration of Angeli’s salt (AS, known HNO donor) to animals results in enhanced cardiac muscle contraction and relaxation. Nitroxyl is also known to be a potent vasodilator. These properties identify HNO as a potential therapeutic for congestive heart failure (CHF). To date, most insights in HNO biology have been gleaned from Angeli’s salt and to a lesser extent other HNO donors such as Piloty’s acid. A more comprehensive array of HNO donor compounds is needed to provide better experimental tools to study HNO biology and aid in the development of HNO-therapeutics. With this goal in mind, this thesis aimed at synthesizing and characterizing novel HNO donor compounds, acyloxy nitro so compounds, that are structurally distinct from AS and release HNO at different rates upon hydrolysis at neutral pH. It \s also devoted for describing their chemical and biological profile and its relation to HNO and the common HNO donor Angeli’s salt.
The dissertation is divided into four mam chapters; introduction, scope of
investigation, results & discussion and experimental.
The introduction chapter describes the signaling molecule NO and its redox cousin nitroxyl (HNO) then describes the chemical biology of HNO. This chapter reviews the reactions of HNO including reactions with thiols, metalloproteins, phosphines and oxygen and provides an idea about some physiological functions of HNO such as vasodilation and possible explanations for this action. This chapter further
The fourth chapter is the experimental part. It describes the detailed experimental procedure for the synthesis of the six main compounds studied during this thesis, namely:
I-Nitrosocyclohexyl acetate (1), I-nitrosocyclohexyl pivalate (2), I-nitrosocyclohexyl trifluoroacetate (3), I-nitrosocyclohexyl 2-acetoxybenzoate (4), I-nitrosocyclohexyl 2-(4 isobutylphenyl)propanoate (5) and I-nitrosocyclohexyl 2-(1-( 4-chlorobenzoyl)-5-methoxy 2-methyl-lH-indol-3-yl)acetate (6).
The remaining of the experimental part is concerned with the evaluation of the newly synthesized compounds. The evaluation includes detailed procedures for studying the rate and products of acyloxy nitroso compound decomposition in the absence and the presence of thiols. This chapter describes the procedure for studying the reaction of these compounds with thiol proteins like AhpC C165S and GAPDH and shows the synthesis of any other compound necessary for the evaluation process. The final parts of the experimental section are concerned with the procedures used for the biological evaluation of the synthesized compounds including vasoactive assays performed on rat aorta strips and anti-cancer assays performed on two breast cancer cell lines (MCF-7 and MDA-231).