الفهرس 
DILATED CARDIOMYOPATHYOnly 14 pages are availabe for public view
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Abstract
This study is a case-controlled analytic study that was conducted in Ain Shams Uiversity Hospital in order to find out the relationship between serum Ferritin level and non-ischemic cardiomyopathy among diabetic and non-diabetic patients.
Thirty patients with dilated cardiomyopathy were included in the study and they were divided into two groups:Group (I) Included 15 patients with type II diabetes mellitus and have dilated cardiomyopathy,Group (II) included another 15 non-diabetic patients with dilated cardiomyopathy.
Patients with ischaemic cardiomyopathy, history of anemia and/or taking iron preparations on admission, Alcoholic liver disease, Hemochromatosis, Hemolytic anemia, Hodgkin’s lymphoma, Megaloblastic anemia, Long-term digestive tract bleeding, Heavy menstrual bleeding, Iron deficiency anemia, anaemia of chronic diseases and bleeding disorders were exclude from the study.
All patients included in the study were subjected to the following :- Full history taking and full clinical examination, Resting (12) lead ECG recorded at 25 mm/ sec, Serum cholesterol, LDL, HDL, TG, CBC, serum blood glucose level, liver and kidney function tests, chest radiograph Transthoracic echocardiography , and Blood samples for laboratory assessment of ferritin level to all patients. All patients have the basic treatment for diabetes and cardiomyopathy.
The data of each patient were collected in a special file then it was fed to the computer on statisitical pckage SPSS/PC for statistical analysis. Discreptive statistics were done including mean, standard deviation and percentage. Comparison between the two groups was done using paired student’s t-test for the non-parametric variables and by Chi-sqaure test for the parmetric variables. Pearson product moment correlation coeffecient was done to find out the presence of significant correlation between the serum ferritin level and the different continuous variables such as duraion of DM, EDD, ESD, EF and fraction shortening.( P < 0.05) was considered significant.
Results of the current study showed that there was highly significant difference between the two groups regarding PAP ( P < 0.01). PAP was high in group I than group II.
Results of the current study showed that there was no significant difference between the two groups regarding their mean age, weight, height, body mass index. There was also no significant difference between the two groups regarding the heart rate, systolic and diastolic blood pressure (P >0.05). There was also significant difference between the two groups regarding their sex (P < 0.01), Male percent was 100% in group I and 46.7% in group II and Female percent was 0% in group I And 53.3% in group II .
Results of the current study showed that there was no significant difference between the two groups regarding the kidney function tests, liver function tests, total cholesterol, LDL and HDL (P > 0.05). The mean blood glucose level and mean triglyceride levels were significantly higher among group I than that of group II (P < 0.001).
Serum ferritin level was 220.5 ± 114.04 in group I versus 140.6 ± 80.8 for group II. The difference between the two groups regarding the serum ferritin level was highly significant (P < 0.001).
Results of the current study showed that the prevalence of hyperferritenemia was significantly higher in group I (6/15 patients, 40%) than that of group II (2/15 patients, 13.3%). Normal serum ferritin level was found in 8patients of group I (53.3%) while it was in 12 patients of group II (80%). Hypoferritenemia was found in 1 patient of both groups (6.7%).
Results of the current study showed that all patients of the two groups had different degrees of diastolic dysfunction. The degree of diastolic dysfunction was found to be significantly more severe in group I than group II (P < 0.01). 3 patients of group I had grade I diastolic dysfunction vs 8 patients (53.3%) of group II, 5 patients of group I (33.3%) had grade II diastolic dysfunction vs 4 patients (26.7%) of group II and 7 patients (46.7%) of group I had grade III diastolic dysfunction vs 3 patients (20%) of group II.
Results of the current study showed that there was significant Correlation between serum ferritin level and F.B.S. in the group I (P < 0.05) but there was no significant Correlation between serum ferritin level and F.B.S. in the groupII (P > 0.05) This due to diabetes and male percent was 100% in group I. and there was no significant Correlation between serum ferritin level and LV systolic function (EF,FS%) in the two groups(P > 0.05) .and there was significant Correlation between F.B.S. and LV systolic function (EF,FS%) in the groupI (P < 0.05) but there was no significant Correlation between F.B.S. and LV systolic function (EF,FS%) in the groupII (P > 0.05).
Our results showed that the duration of diabetes mellitus ranged between 2 to 8 years with a mean of 3.7 ± 1.9 years. There was positive significant correlation between diabetes duration and level of serum ferritin among patients of group I (r = 0.501, P = 0.006).