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Abstract This work has been carried out to present and characterize new plastic membrane and chemically modified carbon paste electrodes for the determination of the oxymetazoline hydrochloride. The electrodes are based on ion-associates formed from the ion-associations of the drug cation with anion of tetraphenylborate, and reineckate. The electrodes were constructed and fully characterized in terms of composition, life span, response time, usable pH range, working concentration range and temperature. Each electrode was applied to the potentiometric determination of the drug cation in the pure solutions and pharmaceutical preparations. • Keywords: Afrin nasal DROP, oxymetazoline hydrochloride, potentiometry, PVC electrode, and chemically modified carbon paste electrode. |