الفهرس 
IntroductioOnly 14 pages are availabe for public view
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Abstract
Background: Hepatic steatosis or fatty liver is a common cause of liver function tests abnormalities, and there is a growing role of adiponectin in the development and the severity of hepatic steatosis. This study was undertaken to determine the effect of exercise, pioglitazone (PGZ) and ferulic acid (FA) on adiponectin level in high fat diet (HFD) induced hepatic steatosis. Methods: 60 Male Sprague-Dawley rats were divided standard diet fed groups with or without exercise and HFD fed groups with or without exercise, PGZ 10 mg/kg/day and FA 20 mg/kg/day for 12 weeks. Results: The HFD induced significant serum dyslipidaemia and significantly increased the liver tissues TG content, the liver enzymes levels and the score of hepatic steatosis. Also the liver tissue oxidative stress markers were significantly increased. Conversely, the serum adiponectin level was significantly lowered. While either concurrent exercise or PGZ or FA with HFD ameliorated the development of hepatic steatosis, and reduced the liver TG content. Also they improved the serum lipid profile and increased the serum adiponectin levels, but decreased the liver enzymes levels and the liver tissue oxidative stress markers. However exercise with HFD produce the highest effect on the reduction of hepatic tissue TG content and Concurrent PGZ with HFD produce the highest increase in the serum adiponectin levels. In conclusion: Exercise, PGZ and FA increase the serum adiponectin levels, and reduce the development of hepatic steatosis.