الفهرس 
PATHOPHYSIOLOGY OF DIABETICOnly 14 pages are availabe for public view
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Abstract
The aim of this study is to correlate between glycemic state (admission hyperglycemia and HbA1c) and the hospital outcome (including 30 days follow up) as regards major cardiac events (morbidity and mortality) in patients with ACS.
This study included 100 patients presented to the emergency room of Ain Shams university hospitals and the National Heart Institute with acute coronary syndrome (unstable angina, ST elevation myocardial infarction and non ST elevation myocardial infarction).
The Patients then classified into 2 groups, Group A which included 50 patients known to be diabetic and Group B which included 50 patients not known to be diabetic. the Inclusion criteria included Patients with ACS (unstable angina, STEMI and non-STEMI) and admitted to the CCU. The exclusion criteria included any patient with end stage disease that might affect prognosis of the patients as advanced malignancy, CRF, and advanced liver disease.
All patients then were subjected to full history taking, physical examination, resting 12 lead ECG, laboratory investigations in the form of random blood sugar on admission (RBS), glycosylated hemoglobin (HBAIc), serum lipids, Troponin I, cardiac specific creatine phosphokinase (CKMB) and high sensitivity C- reactive protein (hs-CRP).
Statistical analysis then done and the results were tabulated and statistical analysis was performed using IBM compatible PC computer and by means of statistical software package namely (SPSS), The results were analyzed by the suitable statistical methods, which included Mean, standard deviation (SD) and Student’s t-test, Data were considered significant at a p value <0.05 highly significant at a p value < 0.01 and non significant at a p value >0.05. Follow up then were done by phone after 1 month.
Our results revealed that there were no statistically significant difference between group A and group B as regards age, sex distribution, prevalence of hypertension, prevalence of cigarette smoking, ST segment deviation, serum lipids, serum Troponin I, serum cardiac specific creatine phosphokinase and serum high sensitivity C- reactive protein which means that these factors had no impact on the outcomes at 30 days follow up in diabetic patients presented by acute coronary syndrome.
Our results also revealed that there were a statistically significant difference between group A and group B as regards serum random blood sugar on admission and serum glycosylated hemoglubin which means that these factors had a significant impact on the outcomes at 30 days follow up in diabetic patients presented by acute coronary syndrome.