الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
This study was conducted on twenty female patients presented with breast lesion. Their age ranged between 15 years and 65 years with a median age of 42.5 years.
The aim of this work was to study the value of Diffusion Weighted MR Imaging for differentiation of benign from malignant breast lesions.
All patients were subjected to full history taking, thorough clinical examination, digitalized mammography, high resolution US, DW MRI imaging and histopathology.
All MRI studies were obtained using a dedicated MRI machine (Siemens, Avanto closed MRI machine) with magnets of intensity field 1.5 T and gradients 20 mT/m, equipped with bilateral dedicated breast coils.
We used to do dynamic analysis with generation of percent enhancement versus time curves performed through positioning of region of interests at least for all identified enhancing lesions with a diameter >5 mm and mass-like morphology according to the MR imaging Breast Imaging Reporting and Data System (BI-RADS) classification, documenting a representative curve for the most suspicious enhancement dynamics.
ADC value calculation was done for all cases with a region of interest (ROI) manually placed with a diameter of 25 _ 5 mm2 on the lesion, avoiding areas of necrosis, haeomorrhage and scarring.
Our studied cases were classified according to the diffusion pattern in the detected lesions into two groups group 1 includes 7 cases showed restricted diffusion (35%) and group 2 includes the remaining 13 cases showed no significant diffusion restriction (65%).
According to the ADC values, 7 lesions showed ADC values in the range of (0.5-0.9 x 10-3 mm2/s) with mean of 0.67 ± 0.15 and were proved pathologically to be malignant.
A total of 13 lesions showed higher ADC values than malignant lesions and were in the range of (1.7-2.7 x 10-3 mm2/s) with mean of 1.98 ± 0.32 and were diagnosed as benign lesions according to the pathological results.
The mean ADC value of the benign lesions was significantly higher than the value of the malignant lesions.
Histopathological correlation was done in all our patients. In the examined 20 patients included in this study 7 cases were classified as malignant and 13 cases were classified as benign according to the final histopathological results.
The correlation between the findings of DWI and histopathological results of different breast lesions showed the value of this sequence as an additive tool that augment the results of dynamic MRI and increase the overall specificity of the study.