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Abstract embryonal carcinoma cell line, may have contributed to the ability of these cells to proliferate and divide. On the other hand, neural stem cells are very promising cell source for neurodegenerative diseases. Neural stem cells isolated from the mouse ventral mesencephalon differentiated into mature neurons expressing MAP-2 and TH after 7 and 14 days in vitro. Transplantation of the 7 and 14 days differentiated neural stem cells showed successful in vivo differentiation as well. Unlike the NT2 cells, the transplanted mouse neural stem cells showed no signs of in vivo proliferation, division or tumor formation. Neural stem cells isolated from the ventral mesencephalon can be used as successful cell source for transplantation in patients with Parkinson’s disease. |