Search In this Thesis
   Search In this Thesis  
العنوان
Differentiation of the Ntera/D1 (NT2) cell line to dopaminergic neurons in three dimensional culture
المؤلف
Aal Shamekh,Rania Mohammed Abdel
هيئة الاعداد
باحث / Rania Mohammed Abdel Aal Shamekh
مشرف / Sawsan Ahmed Abdel Rahman
مشرف / Samuel Saporta
مشرف / Kamal Asaad Ibrahim
مشرف / Salwa Saad Lashin
الموضوع
The dopaminergic nigrostriatal -
تاريخ النشر
2009
عدد الصفحات
186.p:
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
تشريح
تاريخ الإجازة
1/1/2009
مكان الإجازة
جامعة عين شمس - كلية الطب - Anatomy
الفهرس
Only 14 pages are availabe for public view

from 186

from 186

Abstract

embryonal carcinoma cell line, may have contributed to the ability of these cells to proliferate and divide.
On the other hand, neural stem cells are very promising cell source for neurodegenerative diseases. Neural stem cells isolated from the mouse ventral mesencephalon differentiated into mature neurons expressing MAP-2 and TH after 7 and 14 days in vitro. Transplantation of the 7 and 14 days differentiated neural stem cells showed successful in vivo differentiation as well. Unlike the NT2 cells, the transplanted mouse neural stem cells showed no signs of in vivo proliferation, division or tumor formation.
Neural stem cells isolated from the ventral mesencephalon can be used as successful cell source for transplantation in patients with Parkinson’s disease.