الفهرس 
Brain natriuretic peptideOnly 14 pages are availabe for public view
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Abstract
Natriuretic peptides (NPs) are markers of hemodynamic stress on the heart, denoting the neurohumoral activation of the myocardium. B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are the two brain NPs that are derived from the prohormone, proBNP. BNP and NT-proBNP are produced in a 1:1 ratio when the left ventricle is stretched.
N-terminal pro-B-type natriuretic peptide (NT-pro BNP), a biomarker of heart failure, is involved in regulation of the body fluid homeostasis and vascular tone especially in patients with End Stage Renal Failure (ESRD) on regular hemodialysis.
Accordingly, this study included forty four patients of ESRD on regular hemodialysis thrice weekly divided into two groups (group 1 included 21 pateints on highflux hemodialyzer and group 2 included 32 pateints on lowflux hemodialyzers), aiming to study the effect of dialysis membrane type on NT pro BNP and the correlation between NT pro bnp level measured pre and post hemodialysis and parameters of fluid removal during hemodialysis which included weight decrease, systolic and diastolic blood pressure decrease pre and post hemodialysis.
The results of this study showed marked increase in NT pro BNP levels in all patients studied with significant decrease in NT pro BNP level by 53% with highflux dialyzers and 23% decrease with lowflux dialyzers which was significant to prove that NT pro BNP is affected by the type of hemodialyzer and that highflux is more efficient in clearance of pro BNP.
The percentage changes showed no significant correlations between NT pro BNP and all parameters of fluid volume changes during hemodialysis.
There was no significant correlation between percentage changes in pro BNP and weight reduction and both SABP and DABP.
There was a significant correlation between NT pro BNP levels and serum ferritin levels indicating the association between both parameters and inflammatory condition associating hemodialysis.