الفهرس | Only 14 pages are availabe for public view |
Abstract Heart failure is the end stage of all diseases of the heart and is a major cause of morbidity and mortality .Congestive heart failure is the common final pathway for Patients with ischemic & non Ischemic cardiomyopathies. Therapeutic options mainly target on the consequences of heart failure, like this overlaps: & neuro hormonal activation which are Known to be long-term deleterious. However, improvements of ventricular contractility by restoration of cardiomyocyte contractile capacity has not been an issue until recently The organism is made up of two kinds elements; first, the adult cell that cannot revert to the embryonic state & unable to develop regenerative activity; second, the germinal corpuscles, which are undifferentiated cells that are specific to each tissue. These second cells are devoid of useful physiological activity but they do control tissue regeneration, both during normal physiology and in pathological processes. Contrary to the general belief, the restricted regenerative capacity of the myocardium does not represent the initial causal event of impaired cardiac function. The nonischemic failing heart, in its early phases of decompensation, has a number of myocytes that often exceeds the number of cells in a normal heart. Alternatively, the modest reduction in myocyte number chronically is not consistent with the severe deterioration in ventricular performance. In embryonic and early postnatal life. |