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Abstract the thesis consists of four chapters, chapter 1: general introduction - chapter 2: Kinetic investigation and determination of pipoxolan hydrochloride and its degradant using HPLC. Chapter 3: divided into part A, introduction about chemometric-assisted spectrophotometric methods, B, HPLC and chemometric abd assisted spectrophotometry for the simultaneous deterimination of two multicomponents. C, Application of HPLC and HPLC for the simultaneous determination of two multicomponent mixture containing pyridoxine hydrochloride and cyanocobalamine. chapter, 4 divided into 3 parts A, introduction about biological fluids. B, Quantitative determination of levetiracetam in human urine using HPLC-UV and its identification by LC-ESL-MS, C, optimization and validation of HPLC for the determination of eprosartan mesylate in rat plasma and urine. |