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Abstract Clostridium difficile associated diarrhea is the most frequently identified cause of nosocomial diarrhea. C.difficle causes a wide range of clinical syndromes, inducing asymptomatic colonization, antibiotic associated diarrhea and pseudemembrance colitis. Pseudemembrance colitis can progress to megacolon and subsequent death. The current study was done in order to determine the incidence, risk factors of C.difficile infection in PICU. This study was conducted in pediatric ICU, children’s hospitals, Ain Shams University and included 45 patients, in the period between January 2007 to May 2007. Patients were classified into patients with diarrhea group (A 33) and patient without diarrhea group (B) 33 patients without diarrhea group (B) they were 12. For all included patients full medical history was taken thorough clinical examinations was done. Laboratory investigations were done as CBC, CRP, urea, creatinine, SGPT, SGOT, PT, and PTT. The study also included assay of C.difficile toxins A/B in stool collected from patients on the first day of admission and again after 5 days of admission to PICU. |