الفهرس 
Atopic DermatitisOnly 14 pages are availabe for public view
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Abstract
The aim of the present study was to measure CD14 and TLR2 expression on peripheral blood mononuclear cells (PBMCs) in infants and children with atopic dermatitis in order to clarify their potential role in AD and univeil any possible association between the number of PBMCs expressing TLR2/CD14 and the total IgE level.
The present study included 36 children age below 5 years old of both sex, 21 children with AD and 15 healthy children.
All subjects included in this study had full history taking, thorough clinical examination including severity score and laboratory profile including CBC, IgE, CD14 and TLR2 by flowcytometry.
The present study demonstrated non significant statistical difference between patients and controls as regards WBCs, eosinophil count, CD14+ /TLR2+ monocytes %, CD14- /TLR2+ monocytes %, CD14+ /TLR2- monocytes %, CD14- /TLR2- monoctes % and IgE levels.
Non-significant statistical difference was detected between female and male patients as regards all clinical and laboratory data.
Atopic dermatitis patients with family history of atopy had significantly longer duration of illness compared to negative family history group, in addition they had lower Monocytes % , lower CD14+ /TLR2+ monocytes %, higher CD14+ /TLR2- monocytes % and higher CD14- /TLR2- monocytes % , otherwise, non significant statistical difference was detected between both groups.
Among the studied atopic dermatitis children, there is significant statistical positive correlation between serum level of IgE and percentage of eosinophil and also with absolute eosinophil count.
The present study demonstrated significant statistical negative correlation between total score and % CD14+/TLR2+ PBMCs and significant statistical positive correlation between total score and % CD14-/TLR2– PBMCs.
Significant statistical negative correlation between intensity score and % CD14+/TLR2+ PBMCs was demonstrated in addition to significant statistical positive correlation between intensity score and % CD14-/TLR2- PBMCs .
IgE was increased in patients serum than controls but results were not statistically significant