الفهرس 
Introduction and Aim of the Work
Epidemiology Etiology, and pathogenesis of colorectal carcinomaOnly 14 pages are availabe for public view
 |  | from | 16 |  |  |
| | | from | 16 | | |
Abstract
Thirty patients, 15 females (45.5%) and 18 males(54.5%) were included in the study the median age was 40 y (range 18-59). Most of them had adenocarcinoma of the rectum.The main presenting symptoms were bleeding per rectum (60%). Data regarding preoperative chemo-radiotherapy were available for 33 patients (100%). The dose of radiotherapy was 5040 cGy/28ttt, and Capecitabine chemotherapy schedule is 850mg/m2 daily concurrent with radiotherapy. As regard tumor response to neo-adjuvant therapy; 18/33 patients (54.5%) achieved complete response, 8/33 patients (24%) achieved partial response and 7/33 patients (21%) had no response.
Trans-anal abdominally assisted colo-anal pull-through was performed in 27 patients (81.8%) and 6 patients (18 %) underwent abdomino-perineal resection. About the toxicity in this study; for chemotherapy, deep venous thrombosis developed in 5 patients (15 %) and hand-foot syndrome developed in 7 patients (21%). For radiotherapy 19 patients (57.5%) developed wet desquamation. The main post-operative complications were fistula in 2 cases (6%) and partial stump ischemia in 3 (9%).
The study had a median disease free survival of 9.5 months and reported a 85% local control rate and 6.6% local failure rate after a follow up period of 6 months.
The mean progression free survival for the patients who had the protocol of the study were calculated and it can be seen that at 6 months was 9 months .
The mean overall survival for the patients who had undergone this regimen were calculated and it can be seen that at 6 months it was 11 monyhs.
Stage of tumor was the only significant factor affecting the disease free survival and overall survival.
All patients tolerate the treatment protocol and neither associated with life threatening events nor grade 3, grade 4 toxicity.