الفهرس 
POLYCYSTIC OVARIAN SYNDROME (PCOS)Only 14 pages are availabe for public view
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Abstract
A
n increasing number of adolescents are presenting with signs of polycystic ovary syndrome. While once thought to primarily affect appearance and fertility, it has become clear that women with this syndrome may also potentially face long-term health sequelae. Efforts should be made to diagnose and treat these women in adolescence to minimize the development of symptoms, and prevent the onset of cardiovascular and metabolic problems.
Mullerian inhibiting substance is gaining acceptance as a useful marker of female reproductive function, especially with ovulatory disorders and IVF outcomes. Mullerian inhibiting substance offers several advantages to existing screening tests, but establishment of an assay standard should be considered before widespread clinical implementation becomes viable.
Mullerian inhibiting substance is characteristically elevated in polycystic ovarian syndrome, and may be associated with other features of polycystic ovary syndrome such as insulin resistance, hyperandrogenemia, and the degree of anovulation.
The purpose of this work is to compare the level of Anti-Mullerian hormone (AMH) in adolescent girls (11-19) years old with or without polycystic ovary syndrome (PCOS). We studied adolescent girls with (PCOS) n=30 (group A) and normal adolescent girls=30 (group B) as control.
The diagnosis was based on the presence of at least two of the described characteristics, as defined by the Rotterdam Consensus (2004).
Each group subdivided into two subgroup according to body mass index (BMI) <25 AND > 25. Serum from each subgroup was sampled and the following hormones were measured (FSH, LH, DHEAS, Free testesteron, E2, AMH).
The result of our study is increase in the serum level of Anti-Mullerian hormone in adolescent girls with Polycystic Ovary Syndrome irrespective to their BMI.
Also increased serum androgens in girls who have polycystic ovary syndrome in comparison to normal girls. In our study we observe that age of menarch is higher in girls with PCOS. So increased level of AMH may consider to be an early manifestation of Polycystic Ovary Syndrome.