الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
 |  | from | 156 |  |  |
| | | from | 156 | | |
Abstract
Introduction: Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and the third cause of cancer related deaths in the world. In Egypt, it is number one cancer related cause and HCV represents the most important risk factor. Genetic and epigenetic alterations accumulate under the effect of risk factors (viral infections, aflatoxin exposure.etc) and promote the process of carcinogenesis while progression of the tumor requires the selection of altered hepatocytes that have the highest capacity of survival and proliferation. Mutation of p53 (tumor suppressor gene) and overexpression of VEGF (angiogenic factor) are among these important alterations. The aim of this work is to study the expression of p53 and VEGF in both hepatocellular carcinoma tissue and surrounding cirrhotic tissue and to correlate their expression with clinicopathological parameters. Results: 40% of cases were P53 positive. There was statistically positive correlation between age, size and grades of p53 staining (p=0.001).There was significant positive correlation between tumor grade and degree of P53 staining (p=0.000). All cases show negative staining in surrounding cirrhotic tissue. 91.4% of cases were VEGF positive. There was positive correlation between size and VEGF positivity (p=0.355).There was statistical significance between different grades of the tumor and grades of VEGF staining (p=0.003).Conclusions: There was positive correlation between p53 expression and VEGF expression and age of patient, size of the tumor and grade. This should be included in the strategies of target therapy. Absence of p53 expression in surrounding cirrhotic tissue make it useless as a surveillance marker of high risk cirrhotic patients while high expression of VEGF in surrounding cirrhotic tissue makes it good candidate for surveillance for high risk group patients.