الفهرس 
Introduction & aim of the work:Only 14 pages are availabe for public view
 |  | from | 157 |  |  |
| | | from | 157 | | |
Abstract
Childhood obesity is a serious and progressively increasing public health problem that has reached epidemic proportions. Metabolic and cardiovascular complications of obesity in childhood, while less common than in adulthood, may nevertheless include insulin resistance and type 2 diabetes.
This study was carried out to investigate inflammatory status in the form of serum hs-CRP , oxidative stress in the form of urinary PGF-2a, IR indices, early abnormalities of the arterial wall ( defined by IMT ) and associations between above studied parameters, clinical and anthropometric measurements.
The study was carried out on 40 children suffering from obesity aged 4 to 12 years (mean of 9.41± SD1.60), 15 females and 25 males who were selected from out patient clinic at children’s university hospital, faculty of medicine, Minia university. fulfilling the inclusion criteria designed for the study. During the period from April 2009 to April 2010. In addition 25 age and sex matched apparently healthy children were emolled as a control group.
Patients and control were subjected to history taking, full clinical examination including blood pressure, height, weight, BMI, waist circumferance , WHR and body fat percentage calculation by Deurenberg equation and were tested for fasting blood glucose ,2h pps , lipid profile ,serum hs-CRP, insulin resistance indices and urinary PGF - 2a . Right and left CIMT were assessed by high resolution B-mode ultrasound.
In the present study· we that found body mass index (BMI), waist circumference (WC), and diastolic blood pressure (DBP) were significantly higher in obese children than in controls.
We found that fasting insulin level and HOMA-IR were higher in obese group than in controls.
In obese children serum hs-CRP and PGF-2a and were significantly higher compared to controls.
Compared to controls, the mean value of the left and the right carotid arteries were significantly higher in obese pediatric patients.
Moreover we found a significant correlation of HOMA-IR with BMI and WC. There was a significant correlation of PGF-2a with WC and a significant correlation of hs-CRP with WC ,systolic blood pressure (SBP) and diastolic blood pressure (DBP). There was a significant correlation of IMT with BMI, WC , fasting insulin, HOMA-IR, urinary PGF-2u and serum hs-CRP .
Multiple stepwise linear regression analysis revealed that BMI and PGF-2a were the most important and statistically significant factors affecting IMT while the other parameters (WC, BFP%, HDL-cholesterol, fasting insulin, HOMA-IR and hs-CRP) were less important.