الفهرس 
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Abstract
Neonatal jaundice is a term which means yellow discoloration of
skin, mucous membrane and other tissues caused by deposition of bilirubin.
Phototherapy is now the preferred method of treatment of neonatal
hyperbilirubinemia by virtue of its non invasive nature and its relative
freedom from major complications. It is also convenient, easy to use, and
inexpensive in terms of personnel, equipment, and disposals.
One possible harmful consequence of phototherapy is genetic in
nature, as the high fluencies of light used in phototherapy induces DNA
strand breaks,sister chromatid exchanges and mutations.
The aim of our study is to assess if there is a genotoxic effect of
phototherapy in the form of DNA damage in neonates treated with
phototherapy due their indirect hyperbilirubinemia and the relation of this
damage if present to the severity of hyperbilirubinemia and the exposure to
phototherapy and if this damage is persistant or transient, using DNA
fragmentation assay technique.
This study was carried out on (122) neonate selected from neonatal
intensive care unit (NICU) and neonatal out-patient clinic of menoufiya
university hospital.These neonates were subdivided into three groups as
follow:
1-Group of physiological hyperbilirubinemia: this group included 30
neonate having jaundice appearing after the first day with total serum
bilirubin level <13 mg/dl on the second day of life i.e physiologic jaundice.
2-Group of pathological hyperbilirubinemia: this group included 62
neonate, having jaundice on the first day of life or total serum