الفهرس 
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Abstract
Our objective in the present study was to observe the change in the collagenases-1 (MMP-1) concentration as one of the extracellular matrix proteins in tissue and serum samples using polyclonal antibody (anti- MMP-1) and immunochemical techniques in 129 chronic hepatitis C (CHC) (78 fibrotic and 51 with cirrhotic liver) and 50 healthy controls. MMP-1 was detected in the liver tissues of CHC patients by using immunohistochemical staining technique. MMP-1 was detected also in the infected serum samples by using ELISA technique.
The values of MMP-1 concentration increased in patients with CHC according to the stage of liver fibrosis. An area under the ROC curves (AUC) of the MMP-1 was 0.98 for discriminating patients with cirrhotic liver from healthy individuals and was 0.78 for discriminating patients with cirrhotic liver from fibrotic patients. The diagnostic potential of MMP-1 for discriminating cirrhosis from healthy individuals was very high with 98% sensitivity and 97 % efficiency. MMP-1 detected cirrhosis in CHC with 71 % sensitivity and 73% efficiency. Measurement of serum MMP-1 is useful for diagnosing liver cirrhosis in CHC patients.