الفهرس | Only 14 pages are availabe for public view |
Abstract The rapidly increasing and high incidence of breast cancer over the past few decades supports the hypothesis that factors determining breast cancer risk have changed. Some of this change can be directly attributable to a reduction of protective factors (e.g., increasing parity, early age at first birth) in a higher proportion of women .Other factors which are known to increase breast cancer risk (i.e., obesity, low physical activity, and the use of exogenous hormones) have become more common. A significant amount of evidence has accumulated from randomized clinical trials supporting the use of pharmacologic agents for breast cancer risk reduction. All of these trials have capitalized on the known expression of estrogen receptors on many breast cancer cells and the demonstrated efficacy of selective estrogen receptor modulators (SERMs) to treat breast cancer. In Egypt, Screening for breast cancer is currently the most effective available method for secondary prevention. The three commonly used methods are mammography, breast self-examination (BSE), and clinical breast examination (CBE) by trained personnel. |