الفهرس | Only 14 pages are availabe for public view |
Abstract The current study was undertaken to compare the prophylactic effect of green tea extract and interferon-alpha against carbon tetrachloride (CCl4)-induced liver fibrosis in rats. After eight weeks, the rats were sacrificed and were used to: 1. Determinate serum level of liver enzymes. 2. Prepare paraffin sections from left liver lobe for light microscopic study. These sections were stained with: Haematoxylin and eosin (H&E) to study the histological structure, Mallory’s trichrome stain for collagen & Periodic acid Schiff’s (PAS) stain. 3. Prepare frozen sections for studying lipid content with Sudan black stain and demonstrating succinic dehydrogenase activity. 4. Obtain ultrathin sections for transmission electron microscopic study. - Based on the histological, histochemical, ultrastructural and biochemical results, the present study suggests that green tea extract exerts a more potent protective effect than interferon-alpha against both CCl4-induced hepatic fibrosis and non-fibrotic hepatic parenchymal damage in albino rat. |