الفهرس | Only 14 pages are availabe for public view |
Abstract Using of β-(4-bromobenzoyl) acrylic acid in synthesis of heterocyclic compounds:- This thesis describes the utility of β-(4-bromobenzoyl) acrylic as a key starting material for the preparation of a novel series of aroylacrylic acids, pyridazinones and furanones derivatives. Studying the antimicrobial activities of these compounds was performed. Synthesis of 4-(4-bromophenyl)-4-oxobutanioc acid derivatives:- When β-(4-bromobenzoyl) acrylic acid reacts with benzimidazole, anthranilic acid, o-phenylenediamine in ethanol, compounds (I), (V) and (VIII) are yielded respectively. The reaction of β-(4-bromobenzoyl) acrylic acid with ethyl glycinate hydrochloride in the presence of sodium acetate and DROPs of acetic acid in ethanol, compound (XII) is yielded cf. scheme (A). |