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العنوان
Study of the biological effects of some transition metal complexes /
المؤلف
Ragab, Islam Mahmoud Gomaa.
هيئة الاعداد
باحث / Islam Mahmoud Gomaa Ragab
مشرف / EL-Shahat A. Toson
مشرف / Hatem A. El-mezayen
باحث / Islam Mahmoud Gomaa Ragab
الموضوع
Complexes. cytotoxicity. tumors and metastasis.
تاريخ النشر
2012.
عدد الصفحات
225 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
1/1/2012
مكان الإجازة
جامعة دمياط - كلية العلوم - Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

In the present study, the newly synthesized [RuCl3(bipy)C6H5CHO] ,[RuCl3(bipy)p-CH3OC6H4CHO] and [RuCl3(bipy) p-NO2-C6H4CHO] complexes were tested for their cytotoxicities against Eherlich Ascites Cells (EAC) carcinoma, for their superoxide dismutase (SOD)- like activities and for their cytoprotective effects of the normal human red blood cells (RBCs) against photo-irradiation induced by UV-lamb in the presence of m-chloroperbenzoic acid, in vitro. Also, their killing capabilities for the growth of EC carcinoma in vivo in liquid and solid tumor models and the measurements of the biochemical changes accompanying such killing were investigated. Results showed that ruthenium complexes may be used as antioxidant, anti-tumor and anti-metastatic agents in the clinical trials in the future.