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Abstract In the present study, the newly synthesized [RuCl3(bipy)C6H5CHO] ,[RuCl3(bipy)p-CH3OC6H4CHO] and [RuCl3(bipy) p-NO2-C6H4CHO] complexes were tested for their cytotoxicities against Eherlich Ascites Cells (EAC) carcinoma, for their superoxide dismutase (SOD)- like activities and for their cytoprotective effects of the normal human red blood cells (RBCs) against photo-irradiation induced by UV-lamb in the presence of m-chloroperbenzoic acid, in vitro. Also, their killing capabilities for the growth of EC carcinoma in vivo in liquid and solid tumor models and the measurements of the biochemical changes accompanying such killing were investigated. Results showed that ruthenium complexes may be used as antioxidant, anti-tumor and anti-metastatic agents in the clinical trials in the future. |