الفهرس 
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Abstract
Objective: The aim of this work was to evaluate the prognostic value of TNF-α, IL-1β, and IL-1ra genetic polymorphism in SIRS patients.
Patients: In this work 60 patients with SIRS admitted to ICU were included, as well 15 age, sex, weight, and body mass index matched healthy control subject. The patients were divided into two groups of 30 patients each; a group with sepsis and a group with non sepsis. Conclusion: The present results demonstrate that higher serum cytokine levels is related to mortality and a balance towards the anti-inflammatory response might be potentially protective in non septic patients but not in septic condition. TNF-α allele2 polymorphism is associated with higher levels of TNF-α cytokine and poor outcome. In addition, Both TNF-α allele 2 and IL-1ra allele A2 were associated with poor outcome in septic but not in non septic patients; both TNF-α allele 2 and IL-1ra allele A2 may be viewed as predictor of poor outcome in sepsis.