الفهرس 
coverOnly 14 pages are availabe for public view
 |  | from | 188 |  |  |
| | | from | 188 | | |
Abstract
For century , several hundred of pesticides have been used in agricultural practice in order to enhance food production by eradicating unwanted insects and controlling disease vector. Acaricides as fenpyroximate are used for the control parasitic mites, it can be divided into three categories: synthetic organics, natural products and organic acid pesticides. Synthetic organic acaricides include fenpyroximate, a pyrazole acaricide that presumably kills mites through inhibition of electron transport in the mitochondria, thus interfering with energy metabolism. Fenpyroximate is a potential hazard to non target organisms including human.
In this domain, the present study was planned to clarify the toxicological effects (oxidative stress and endocrine disruption effects) of fenpyroximate according to samples on albino rats, and to investigate the role of natural antioxidants (N-Acetyl cysteine and Alpha lipoic acid) as a protective potential for these toxicological effects.
90 males albino rats were allocated for the present study. After acclimatization period of two week, animals were divided into 9 groups according to the dose and duration of exposure. Each group of rats treated as follow:
• Group 1 (c): served as control.
• Group 2 (+ve ALA): rats were orally treated with antioxidant (ALA), 5 days per week for 28 days.
• Group3 (+ve NAC): rats were orally treated with antioxidant (NAC), 5 days per week for 28 days.
• Group 4 (HP): rats were orally treated with high dose of pesticide for 14 days.
• Group 5 (HP + ALA): rats were orally treated with (ALA) after administration of high dose of pesticide for 14 days.
• Group 6 (HP + NAC): rats were orally treated with antioxidant (NAC) after administration of high dose of pesticide for 14 days.
• Group 7(LP): rats were orally treated with low dose of pesticide for 28 days.
• Group 8 (LP +ALA): rats were orally treated with antioxidant (ALA) after administration of low dose of pesticide for 28 days.
• Group 9 (LP + NAC): rats were orally treated with antioxidant (NAC) after administration of low dose of pesticide for 28 days.
After the one month of treatment, ten rats from each group were anaesthetized by ether inhalation, blood samples were collected by means of capillary glass tube insertrd into retro-orbital venous plexus and subjected to biochemical studies to evaluate the oxidative stress status (ATPase, TAC, SH-Protein and MDA), thyroid and pancreatic function markers. At the end of the experimental period, all animals were dissected for histopayhological examination of the thyroid and pancreas gland.
The results of the present study were tabulated and statistically analyzed, this achieved results revealed that fenpyroximate induced oxidative stress, which have been demonstrated by inhibition in TAC and SH-Protein, also elevation in MDA. Beside it there’s an alteration in thyroid and pancreatic function markers.
Histological results revealed that fenpyroximate intoxication induced histological alteration in endocrine organs while antioxidant supplementation had
a protective effect.
In conclusion, the results of this study clearly indicate that fenpyroximate intoxication lead to significant oxidative damage and a compromised antioxidant status and also impairment in thyroid and pancreatic function markers.
Administration of ALA or NAC produced protective role against
toxicity of fenpyroximate.