الفهرس 
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Abstract
DNA fingerprinting of some genes associated with cancer )~juch as breast cancer 1 (BRCAl) and protein 53 (P53) tumor suppressor genes) and H-ras (oncogene) could be ”Considered a useful tool for diagnosis, prognosis and .monitoring the chemo-preventive effects of natural or
,’pharmaceutical compounds. N-methyl-N-nitrosourea (MNU), a carcinogen induces experimental adenocarcinomas in rat awnmary gland with high specificity. Dietary components ve recently received rapidly expanding attention for their
,’potential to halt or reverse the development or progression of cancer. The present study was conducted to evaluate the ”chemopreventive effects of Propolis, Broccoli and Hops as
’”
nutritional components against MNU carcinogen induced
toxication in rats. A daily dose of Pro polis (50 mg/kg BW), ’. roccoli (20 mg/kg BW) or Hops (500 mg/kg BW) were iven to 50 days old female rats for twelve successive weeks carcinogen intoxication with a single dose ofN-methyl--nitrosourea (MNU). Carcinogen intoxication resulted in ox imbalance in hepatic tissue homogenate as well as eased DNA damage indices and decreased lipid profile in DCWLUllary tissue. It also induced allelic imbalance in BRCA 1 and mutations in both exon 7 of p53 and codon 12 of genes. The nutritional supplements ameliorated the
adverse effects induced by MNU carcinogen intoxicati increasing the level of GSH and SOD activity and deer the MDA level with concomitant lowering in fragmentation and DPCLXs. They also gave a protection against the mutational effect of MNU studied genes. Propolis, Broccoli and Hops as components had a strong chemo-protective effect oxidative stress and DNA damage and mutations indu
MNU intoxication in rats.