الفهرس 
Approaches for identifying genes of susceptibilityOnly 14 pages are availabe for public view
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Abstract
• The human genetics play a major role in inter-individual variability in the course of human infections .
• For over 50 years many genetic studies have been used to identify loci for many major causes of human infectious mortality.
• Genetic controlling of infections occurs through interaction between the infectious pathogen and different immunological pathways.
• Molecular genetic testing can supply genetic information to predict IDs risk in individuals.
• Genetic counseling plays a critical role in the appropriate use of these tests.
• Pre symptomatic and predictive genetic testing or carrier genetic testing of minors is the subject of multiple international guidelines and position papers.
• It is important to stress that such predictive testing can be recommended if the results are of direct benefit to the minor, through either access to specific treatment or to preventative therapy .
• Pre-implantation genetic diagnosis of IDs susceptibility has many benefits for the couple, and is likely to become more successful in the future.
• Prenatal diagnosis of IDs susceptibility enables a couple to identify a susceptible fetus and then make decisions about the outcome of that pregnancy. If the couple chooses to continue the pregnancy, early treatment of a susceptible child can occur.
• Universal newborn screening for SCID is waited with great interest .
• Recently there has been interest in community screening for SCID.
• Screening of at-risk relatives will be beneficial in early detection of IDs in certain families.
• We need to create the next generation of clinician -scientists who are capable of translating discoveries of bench research to solve clinical problems in the ward.
• Personalized medicine will soon be a reality in the near future in the field of diagnosis, prophylaxis, and therapy.