الفهرس 
Anatomy of the liver and biliary systemOnly 14 pages are availabe for public view
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Abstract
Cholestasis is an impairment of bile formation and/or bile flow. It is classified into intrahepatic (e.g. Intrahepatic cholestasis of pregnancy, primary biliary cirrhosis, primary sclerosing cholangitis) and extrahepatic (e.g. Cholangiocarcinoma, Cholelithiasis).
Fatigue, pruritus and jaundice are the main presenting symptoms of cholestasis. Initial laboratory tests include elevated serum bilirubin level with a preponderance of the conjugated fraction, also elevated the serum alkaline phosphatase.
There are different imaging modalities can be used for diagnosis of cholestasis e.g. Ultrasound, Computed tomography, MRCP, EUS, ERCP &Trans-hepatic cholangiography. Ultrasound is the first-line non-invasive imaging procedure in order to differentiate intra- from extrahepatic cholestasis.
Long standing cholestasis may be complicated with osteoporosis, steatorrhea, vitamins deficiency, hyperlipidemia, liver cirrhosis, oesophageal varices, hepatocellular failure, and hepatocellular carcinoma.
The goal of therapy in cholestatic liver disease is to eliminate its cause and treat the consequences.