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Abstract One of the common aberrations seen in non-Hodgkin’s lymphoma (NHL) is t(14;18)(q32;21.3). The aim of this work is to study the incidence and quantity of t(14;18) in B-NHL. 33 patients with B-NHL and 10 controls with non-neoplastic lymphoid tissue disorder were tested for quantitation of t(14;18) by real-time quantitative PCR (RQ-PCR). The incidence of t(14;18) was 6.1% among NHLs, 14.3% among follicular lymphomas (FLs), 5.6% among diffuse large cell lymphomas (DLCLs) and 10% among control group. The value of relative quantification for patients was (1.20 and 0.85), while for control case was (0.6). RQ-PCR is a sensitive and specific procedure. It is an ideal tool for follow-up and quantification of minimal residual disease (MRD). Keywords: Real-time PCR, t(14;18). |